Network Physiology: Mapping interactions between complex physiological systems (Prof. P. Ivanov)

Network Physiology: Mapping interactions between complex physiological systems Seminario del Prof. Plamen Ch. Ivanov (Physics Department, Boston University and Division of Sleep Medicine, Harvard Medical School) 16 maggio, ore 16:00, Aula Multimediale Abstract: The human organism is an integrated network where complex physiological systems, each with its own regulatory mechanisms, continuously interact, and where failure of one system can trigger a breakdown of the entire network. Identifying and quantifying dynamical networks of diverse systems with different types of interactions is a challenge. We propose a framework to probe interactions among diverse systems, and we identify a physiological network. We find that each physiological state is characterized by a specific network structure, demonstrating a robust interplay between network topology and function. Across physiological states, the network undergoes topological transitions associated with fast reorganization of physiological interactions on time scales of a few minutes, indicating high network flexibility in response to perturbations. The proposed system-wide integrative approach facilitates the development of a new field, Network Physiology.

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Relatore:Prof. Plamen Ch. Ivanov (Boston U. & Harvard Medical School)